| Gene Information | |
|---|---|
| Gene Name | SLC12A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1212 |
| Protein Names | Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) |
| Target Name | solute carrier family 12 member 2 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000064651 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P55011 |
| Gene Card | SLC12A2 |
| Uniprot ID | P55011 |
| Pfam | PF00324; PF08403; PF03522 |
| In ASD | no |
| Allosteric Prediction | yes (0.955603276) |
| Ortholog in Animals | Alpaca_ SLC12A2 ( ortholog_one2one ) Dog_ SLC12A2 ( ortholog_one2one ) GuineaPig_ SLC12A2 ( ortholog_one2one ) Macaque_ SLC12A2 ( ortholog_one2one ) Mouse_ Slc12a2 ( ortholog_one2one ) Pig_ SLC12A2 ( ortholog_one2one ) Rat_ Slc12a2 ( ortholog_one2one ) Rabbit_ SLC12A2 ( ortholog_one2one ) |
| Ohnologs | SLC12A1 |
| Paralogs | SLC12A8, SLC12A7, SLC12A1, SLC12A4, SLC12A3, SLC12A5, SLC12A6, SLC12A9 |
| Tissue | NA |
| Tissue Specificity | Expressed in many tissues. {ECO:0000269|PubMed:7629105}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6PZT (EM 3.46A ) 7D10 (EM 3.52A ) 7S1X (EM 2.90A ) 7S1Y (EM 3.60A ) 7S1Z (EM 3.30A ) |
| DBSNP | rs1761279419 rs537215758 rs1581138934 rs1763563407 rs1581138944 rs1581138965 |
| Subcellular location [CC] | Basolateral cell membrane {ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:7629105}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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