| Gene Information | |
|---|---|
| Gene Name | SLC10A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 348 |
| Protein Names | Ileal sodium/bile acid cotransporter (Apical sodium-dependent bile acid transporter) (ASBT) (Ileal Na(+)/bile acid cotransporter) (Ileal sodium-dependent bile acid transporter) (IBAT) (ISBT) (Na(+)-dependent ileal bile acid transporter) (Sodium/taurocholate cotransporting polypeptide, ileal) (Solute carrier family 10 member 2) |
| Target Name | ileal sodium/bile acid cotransporter |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000125255 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q12908 |
| Gene Card | SLC10A2 |
| Uniprot ID | Q12908 |
| Pfam | PF01758 |
| In ASD | no |
| Allosteric Prediction | no (-0.070740604) |
| Ortholog in Animals | Alpaca_ SLC10A2 ( ortholog_one2one ) Dog_ SLC10A2 ( ortholog_one2one ) GuineaPig_ SLC10A2 ( ortholog_one2one ) Macaque_ SLC10A2 ( ortholog_one2one ) Mouse_ Slc10a2 ( ortholog_one2one ) Pig_ SLC10A2 ( ortholog_one2one ) Rat_ Slc10a2 ( ortholog_one2many ) Rabbit_ SLC10A2 ( ortholog_one2one ) |
| Ohnologs | SLC10A3, SLC10A4, SLC10A6 |
| Paralogs | SLC10A6, SLC10A4, SLC10A1, SLC10A3, SLC10A5 |
| Tissue | small.intestine, duodenum, kidney, small.intestine.Peyers.patch |
| Tissue Specificity | Mainly expressed in ileum and kidney, lower expression in cecum. {ECO:0000269|PubMed:9458785}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs55971546 rs60380298 rs188096 rs121917848 rs72547505 rs56398830 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | HPG |
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