| Gene Information | |
|---|---|
| Gene Name | SLAMF7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 335 |
| Protein Names | SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319) |
| Target Name | slam family member 7 slamf7 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000026751 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9NQ25 |
| Gene Card | SLAMF7 |
| Uniprot ID | Q9NQ25 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.840703714) |
| Ortholog in Animals | Alpaca_ SLAMF7 ( ortholog_one2one ) Dog_ SLAMF7 ( ortholog_one2one ) GuineaPig_ SLAMF7 ( ortholog_one2one ) Macaque_ SLAMF7 ( ortholog_one2one ) Mouse_ Slamf7 ( ortholog_one2one ) Pig_ SLAMF7 ( ortholog_one2one ) Rat_ Slamf7 ( ortholog_one2one ) Rabbit_ SLAMF7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLAMF9, SLAMF6, CD84, LY9, CD244, CD2, SLAMF8, SLAMF1, CD48 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1. {ECO:0000269|PubMed:11220635, ECO:0000269|PubMed:11698418, ECO:0000269|PubMed:11802771, ECO:0000269|PubMed:12242590, ECO:0000269|PubMed:23695528}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs35325048 rs2295617 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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