| Gene Information | |
|---|---|
| Gene Name | SLA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 261 |
| Protein Names | Src-like-adapter 2 (Modulator of antigen receptor signaling) (MARS) (Src-like adapter protein 2) (SLAP-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000101082 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9H6Q3 |
| Gene Card | SLA2 |
| Uniprot ID | Q9H6Q3 |
| Pfam | PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.354700502) |
| Ortholog in Animals | Alpaca_ SLA2 ( ortholog_one2one ) Dog_ SLA2 ( ortholog_one2one ) GuineaPig_ SLA2 ( ortholog_one2one ) Macaque_ SLA2 ( ortholog_one2one ) Mouse_ Sla2 ( ortholog_one2one ) Pig_ SLA2 ( ortholog_one2one ) Rat_ Sla2 ( ortholog_one2one ) Rabbit_ SLA2 ( ortholog_one2one ) |
| Ohnologs | SLA |
| Paralogs | SLA, DAPP1, SH2D5, NCK1, GRAP, GRAPL, GRB2, GRAP2, NCK2 |
| Tissue | appendix, bone.marrow, colon, dura.mater, gall.bladder, lung, lymph.node, spleen, submandibular.gland, whole.blood |
| Tissue Specificity | Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4M4Z (X-ray 2.10A ) |
| DBSNP | rs34834764 |
| Subcellular location [CC] | Cytoplasm.; [Isoform 1]: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.; [Isoform 2]: Cytoplasm {ECO:0000305}. Note=May be cytoplasmic and is not localized to membranes. |
| Mouse PG classification | NA |
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