| Gene Information | |
|---|---|
| Gene Name | SKP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 424 |
| Protein Names | S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000145604 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q13309 |
| Gene Card | SKP2 |
| Uniprot ID | Q13309 |
| Pfam | PF12937 |
| In ASD | no |
| Allosteric Prediction | yes (0.183630397) |
| Ortholog in Animals | Alpaca_ SKP2 ( ortholog_one2one ) Dog_ SKP2 ( ortholog_one2one ) Macaque_ SKP2 ( ortholog_one2one ) Mouse_ Skp2 ( ortholog_one2one ) Pig_ SKP2 ( ortholog_one2one ) Rat_ Skp2 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | FBXL22, FBXL3, FBXL13, FBXL17, FBXL16, FBXL19, FBXL5, FBXL18, FBXL14, FBXL2, FBXL20, FBXL6, FBXL4, FBXL15, FBXL7 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.036(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FQV (X-ray 2.80A ) 1FS1 (X-ray 1.80A ) 1FS2 (X-ray 2.90A ) 1LDK (X-ray 3.10A ) 2ASS (X-ray 3.00A ) 2AST (X-ray 2.30A ) 7B5L (EM 3.80A ) 7B5M (EM 3.91A ) 7B5R (EM 3.80A ) 7LUO (X-ray 3.17A ) |
| DBSNP | rs3913486 rs3913487 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:22770219}. Nucleus {ECO:0000269|PubMed:22770219}. |
| Mouse PG classification | NA |
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