| Gene Information | |
|---|---|
| Gene Name | SKA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 255 |
| Protein Names | Spindle and kinetochore-associated protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000154839 ) 3 ( ENSG00000262634 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96BD8 |
| Gene Card | SKA1 |
| Uniprot ID | Q96BD8 |
| Pfam | PF07160 |
| In ASD | no |
| Allosteric Prediction | no (-0.999943528) |
| Ortholog in Animals | Alpaca_ SKA1 ( ortholog_one2one ) Dog_ SKA1 ( ortholog_one2one ) GuineaPig_ SKA1 ( ortholog_one2one ) Macaque_ SKA1 ( ortholog_one2one ) Mouse_ Ska1 ( ortholog_one2one ) Pig_ SKA1 ( ortholog_one2one ) Rat_ Ska1 ( ortholog_one2one ) Rabbit_ SKA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.029817(Mouse);NULL(Rat);0.020000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4AJ5 (X-ray 3.32A ) 4C9Y (X-ray 2.01A ) 4CA0 (X-ray 2.26A ) |
| DBSNP | rs6507992 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15561729}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17093495}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner (PubMed:17093495). Localizes to both the mitotic spindle and kinetochore-associated proteins (PubMed:17093495). Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase (PubMed:17093495). {ECO:0000269|PubMed:17093495}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |