| Gene Information | |
|---|---|
| Gene Name | SK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 654 |
| Protein Names | Sphingosine kinase 2 (SK 2) (SPK 2) (EC 2.7.1.91) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NRA0 |
| Gene Card | SPHK2 |
| Uniprot ID | Q9NRA0 |
| Pfam | PF00781; PF19279 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in adult kidney, liver, and brain (PubMed:10751414). Expressed in cerebral cortex and hippocampus (at protein level) (PubMed:29615132). Isoform 1 is the predominant form expressed in most tissues (PubMed:16103110). {ECO:0000269|PubMed:10751414, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:29615132}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11881285 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:17635916, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:29615132}. Nucleus {ECO:0000269|PubMed:12954646, ECO:0000269|PubMed:16103110, ECO:0000269|PubMed:17635916, ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:29615132}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9JIA7}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9JIA7}. Note=In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656). In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132). In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547). {ECO:0000269|PubMed:19729656, ECO:0000269|PubMed:20197547, ECO:0000269|PubMed:29615132}.; [Isoform 2]: Lysosome membrane {ECO:0000269|PubMed:17897319}. |
| Mouse PG classification | NA |
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