| Gene Information | |
|---|---|
| Gene Name | SIX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 291 |
| Protein Names | Homeobox protein SIX2 (Sine oculis homeobox homolog 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000170577 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPC8 |
| Gene Card | SIX2 |
| Uniprot ID | Q9NPC8 |
| Pfam | PF00046; PF16878 |
| In ASD | no |
| Allosteric Prediction | no (-0.862618519) |
| Ortholog in Animals | Alpaca_ SIX2 ( ortholog_one2one ) Dog_ SIX2 ( ortholog_one2one ) GuineaPig_ SIX2 ( ortholog_one2one ) Macaque_ SIX2 ( ortholog_one2one ) Mouse_ Six2 ( ortholog_one2one ) Pig_ SIX2 ( ortholog_one2one ) Rat_ Six2 ( ortholog_one2one ) Rabbit_ SIX2 ( ortholog_one2one ) |
| Ohnologs | SIX1 |
| Paralogs | ANHX, SIX6, SIX3, SIX1, SIX4, SIX5 |
| Tissue | salivary.gland |
| Tissue Specificity | Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of fetal kidney (at protein level). {ECO:0000269|PubMed:22703800}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.111111(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs142188105 rs147806994 rs201675842 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q62232}. |
| Mouse PG classification | NA |
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