| Gene Information | |
|---|---|
| Gene Name | SIX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 284 |
| Protein Names | Homeobox protein SIX1 (Sine oculis homeobox homolog 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000126778 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15475 |
| Gene Card | SIX1 |
| Uniprot ID | Q15475 |
| Pfam | PF00046; PF16878 |
| In ASD | no |
| Allosteric Prediction | no (-1.002813689) |
| Ortholog in Animals | Alpaca_ SIX1 ( ortholog_one2one ) Dog_ SIX1 ( ortholog_one2one ) GuineaPig_ SIX1 ( ortholog_one2one ) Macaque_ SIX1 ( ortholog_one2one ) Mouse_ Six1 ( ortholog_one2one ) Pig_ SIX1 ( ortholog_one2one ) Rat_ Six1 ( ortholog_one2one ) Rabbit_ SIX1 ( ortholog_one2one ) |
| Ohnologs | SIX2 |
| Paralogs | SIX2, ANHX, SIX6, SIX3, SIX4, SIX5 |
| Tissue | salivary.gland, skeletal.muscle, brain |
| Tissue Specificity | Specifically expressed in skeletal muscle. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4EGC (X-ray 1.99A ) |
| DBSNP | rs397515562 rs17850414 rs397515560 rs1064794308 rs80356459 rs397515561 rs121909770 rs104894478 rs80356460 rs368974927 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10801845, ECO:0000269|PubMed:17130831, ECO:0000269|PubMed:19497856}. Cytoplasm. |
| Mouse PG classification | NA |
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