| Gene Information | |
|---|---|
| Gene Name | SIT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 196 |
| Protein Names | Signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein) (Suppression-inducing transmembrane adapter 1) (gp30/40) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000137078 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9Y3P8 |
| Gene Card | SIT1 |
| Uniprot ID | Q9Y3P8 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.195155679) |
| Ortholog in Animals | Alpaca_ SIT1 ( ortholog_one2one ) Dog_ SIT1 ( ortholog_one2one ) GuineaPig_ SIT1 ( ortholog_one2one ) Macaque_ SIT1 ( ortholog_one2one ) Mouse_ Sit1 ( ortholog_one2one ) Pig_ SIT1 ( ortholog_one2one ) Rat_ Sit1 ( ortholog_one2one ) Rabbit_ SIT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | appendix, lymph.node, spleen, tonsil |
| Tissue Specificity | Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. {ECO:0000269|PubMed:10209036, ECO:0000269|PubMed:16160011}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10209036}; Single-pass type I membrane protein {ECO:0000269|PubMed:10209036}. |
| Mouse PG classification | NA |
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