Gene Information
Gene NameSIRT7
OrganismHomo sapiens (Human)
Gene Length400
Protein NamesNAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000187531 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ9NRC8
Gene CardSIRT7
Uniprot IDQ9NRC8
PfamPF02146
In ASDno
Allosteric Predictionno (-0.236261514)
Ortholog in AnimalsAlpaca_ SIRT7 ( ortholog_one2one )
Dog_ SIRT7 ( ortholog_one2one )
GuineaPig_ SIRT7 ( ortholog_one2one )
Macaque_ SIRT7 ( ortholog_one2one )
Mouse_ Sirt7 ( ortholog_one2one )
Pig_ SIRT7 ( ortholog_one2one )
Rat_ Sirt7 ( ortholog_one2one )
OhnologsNA
ParalogsSIRT2, SIRT4, SIRT1, SIRT3, SIRT5, SIRT6
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5IQZ  (X-ray  2.33A  )  6G0S  (X-ray  1.48A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus, nucleolus {ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:19174463, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:30420520}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:31075303}. Chromosome {ECO:0000269|PubMed:27436229, ECO:0000269|PubMed:31226208}. Cytoplasm {ECO:0000269|PubMed:11953824}. Note=Mainly localizes in the nucleolus and nucleoplasm (PubMed:24207024, PubMed:28886238, PubMed:28790157, PubMed:31075303). Associated with rDNA promoter and transcribed region (PubMed:16079181, PubMed:19174463). Associated with nucleolar organizer regions during mitosis (PubMed:16079181, PubMed:19174463). In response to stress, released from nucleolus to nucleoplasm (PubMed:24207024). Associated with chromatin (PubMed:22722849). In response to DNA damage, recruited to DNA double-strand breaks (DSBs) sites (PubMed:27436229) (Probable). Located close to the nuclear membrane when in the cytoplasm (PubMed:11953824). {ECO:0000269|PubMed:11953824, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:19174463, ECO:0000269|PubMed:22722849, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:27436229, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:31075303, ECO:0000305|PubMed:30944854}.
Mouse PG classificationNA
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