| Gene Information | |
|---|---|
| Gene Name | SIRT5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 310 |
| Protein Names | NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5) |
| Target Name | nad-dependent protein deacylase sirtuin-5, mitochondrial |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000124523 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9NXA8 |
| Gene Card | SIRT5 |
| Uniprot ID | Q9NXA8 |
| Pfam | PF02146 |
| In ASD | no |
| Allosteric Prediction | yes (0.56151276) |
| Ortholog in Animals | Alpaca_ SIRT5 ( ortholog_one2one ) Dog_ SIRT5 ( ortholog_one2one ) GuineaPig_ SIRT5 ( ortholog_one2one ) Macaque_ SIRT5 ( ortholog_one2one ) Mouse_ Sirt5 ( ortholog_one2one ) Pig_ SIRT5 ( ortholog_one2one ) Rat_ Sirt5 ( ortholog_one2one ) Rabbit_ SIRT5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SIRT7, SIRT2, SIRT4, SIRT1, SIRT3, SIRT6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10381378}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2B4Y (X-ray 1.90A ) 2NYR (X-ray 2.06A ) 3RIG (X-ray 2.00A ) 3RIY (X-ray 1.55A ) 4F4U (X-ray 2.00A ) 4F56 (X-ray 1.70A ) 4G1C (X-ray 1.94A ) 4HDA (X-ray 2.60A ) 5BWL (X-ray 1.55A ) 5XHS (X-ray 2.19A ) 6ACE (X-ray 1.98A ) 6ACL (X-ray 1.92A ) 6ACO (X-ray 1.71A ) 6ACP (X-ray 2.30A ) 6EQS (X-ray 1.32A ) 6LJK (X-ray 1.39A ) 6LJM (X-ray 1.78A ) 6LJN (X-ray 1.80A ) |
| DBSNP | rs9464003 rs34162626 |
| Subcellular location [CC] | Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.; [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:21143562}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:21143562}.; [Isoform 2]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:21143562}. |
| Mouse PG classification | NA |
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