| Gene Information | |
|---|---|
| Gene Name | SIRT3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 399 |
| Protein Names | NAD-dependent protein deacetylase sirtuin-3, mitochondrial (hSIRT3) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 3) (SIR2-like protein 3) |
| Target Name | nad-dependent protein deacetylase sirtuin-3, mitochondrial |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000142082 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NTG7 |
| Gene Card | SIRT3 |
| Uniprot ID | Q9NTG7 |
| Pfam | PF02146 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999799093) |
| Ortholog in Animals | Alpaca_ SIRT3 ( ortholog_one2one ) Dog_ SIRT3 ( ortholog_one2one ) GuineaPig_ SIRT3 ( ortholog_one2one ) Macaque_ SIRT3 ( ortholog_one2one ) Mouse_ Sirt3 ( ortholog_one2one ) Pig_ SIRT3 ( ortholog_one2one ) Rat_ Sirt3 ( ortholog_one2one ) Rabbit_ SIRT3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SIRT7, SIRT2, SIRT4, SIRT1, SIRT5, SIRT6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10381378, ECO:0000269|PubMed:12374852}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3GLR (X-ray 1.80A ) 3GLS (X-ray 2.70A ) 3GLT (X-ray 2.10A ) 3GLU (X-ray 2.50A ) 4BN4 (X-ray 1.30A ) 4BN5 (X-ray 3.25A ) 4BV3 (X-ray 2.00A ) 4BVB (X-ray 2.00A ) 4BVE (X-ray 2.05A ) 4BVF (X-ray 2.70A ) 4BVG (X-ray 2.50A ) 4BVH (X-ray 1.90A ) 4C78 (X-ray 2.00A ) 4C7B (X-ray 2.10A ) 4FVT (X-ray 2.47A ) 4FZ3 (X-ray 2.10A ) 4HD8 (X-ray 2.30A ) 4JSR (X-ray 1.70A ) 4JT8 (X-ray 2.26A ) 4JT9 (X-ray 2.24A ) 4O8Z (X-ray 2.00A ) 5BWN (X-ray 1.94A ) 5BWO (X-ray 2.38A ) 5D7N (X-ray 1.83A ) 5H4D (X-ray 3.21A ) 5Y4H (X-ray 2.60A ) 5YTK (X-ray 2.70A ) 5Z93 (X-ray 1.95A ) 5Z94 (X-ray 1.90A ) 5ZGC (X-ray 2.90A ) 6ISO (X-ray 2.95A ) |
| DBSNP | rs28365927 rs11246020 rs3020901 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}. |
| Mouse PG classification | NA |
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