Gene Information
Gene NameSIRT1
OrganismHomo sapiens (Human)
Gene Length747
Protein NamesNAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Target Namenad-dependent deacetylase sirtuin-1
Target TypeClinical trial target
Gene Age1488 ( ENSG00000096717 )
Evolutionary StageCellular_organisms
AlphaFoldDBQ96EB6
Gene CardSIRT1
Uniprot IDQ96EB6
PfamPF02146
In ASDyes
Allosteric Predictionyes (1.531976597)
Ortholog in AnimalsAlpaca_ SIRT1 ( ortholog_one2one )
Alpaca_ SIRT1 ( ortholog_one2many )
GuineaPig_ SIRT1 ( ortholog_one2one )
Macaque_ SIRT1 ( ortholog_one2one )
Mouse_ Sirt1 ( ortholog_one2one )
Pig_ SIRT1 ( ortholog_one2one )
Rat_ Sirt1 ( ortholog_one2one )
Rabbit_ SIRT1 ( ortholog_one2one )
OhnologsNA
ParalogsSIRT7, SIRT2, SIRT4, SIRT3, SIRT5, SIRT6
TissueNA
Tissue SpecificityWidely expressed. {ECO:0000269|PubMed:10381378}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.019672(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4I5I  (X-ray  2.50A  )  4IF6  (X-ray  2.25A  )  4IG9  (X-ray  2.64A  )  4KXQ  (X-ray  1.85A  )  4ZZH  (X-ray  3.10A  )  4ZZI  (X-ray  2.73A  )  4ZZJ  (X-ray  2.74A  )  5BTR  (X-ray  3.20A  ) 
DBSNP rs35671182  rs1063111 
Subcellular location [CC]Nucleus, PML body {ECO:0000269|PubMed:12006491}. Cytoplasm {ECO:0000269|PubMed:20027304}. Nucleus {ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20027304, ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:20955178}. Note=Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491). Colocalized with APEX1 in the nucleus (PubMed:19934257). May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825). Shuttles between nucleus and cytoplasm (By similarity). Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20955178}.;
[SirtT1 75 kDa fragment]: Cytoplasm {ECO:0000269|PubMed:21987377}. Mitochondrion {ECO:0000269|PubMed:21987377}.
Mouse PG classificationNA
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