| Gene Information | |
|---|---|
| Gene Name | SIRPG |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | Signal-regulatory protein gamma (SIRP-gamma) (CD172 antigen-like family member B) (Signal-regulatory protein beta-2) (SIRP-b2) (SIRP-beta-2) (CD antigen CD172g) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000089012 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9P1W8 |
| Gene Card | SIRPG |
| Uniprot ID | Q9P1W8 |
| Pfam | PF07654; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.427875998) |
| Ortholog in Animals | Alpaca_ SIRPG ( ortholog_one2one ) Macaque_ SIRPG ( ortholog_one2one ) Mouse_ Sirpb1a ( ortholog_many2many ) Mouse_ Sirpb1b ( ortholog_many2many ) Mouse_ Sirpb1c ( ortholog_many2many ) Mouse_ Sirpa ( ortholog_many2many ) Mouse_ Gm5150 ( ortholog_many2many ) Mouse_ Gm9733 ( ortholog_many2many ) Rat_ Sirpd ( ortholog_many2many ) Rat_ Sirpb2 ( ortholog_many2many ) Rat_ Sirpa ( ortholog_many2many ) Rat_ AABR07006142.1 ( ortholog_many2many ) Rat_ AABR07008876.1 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | SIRPA, SIRPB1, SIRPD, SIRPB2 |
| Tissue | lymph.node, tonsil |
| Tissue Specificity | Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. {ECO:0000269|PubMed:11185750, ECO:0000269|PubMed:15383453}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2JJW (X-ray 1.70A ) 4I2X (X-ray 2.48A ) |
| DBSNP | rs6043409 rs6034239 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:15383453}; Single-pass type I membrane protein {ECO:0000269|PubMed:15383453}. |
| Mouse PG classification | NA |
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