| Gene Information | |
|---|---|
| Gene Name | TLCD3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 274 |
| Protein Names | Ceramide synthase (EC 2.3.1.-) (Protein FAM57B) (TLC domain-containing protein 3B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000149926 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q71RH2 |
| Gene Card | TLCD3B |
| Uniprot ID | Q71RH2 |
| Pfam | PF03798 |
| In ASD | no |
| Allosteric Prediction | no (-1.513697462) |
| Ortholog in Animals | Alpaca_ TLCD3B ( ortholog_one2one ) Dog_ TLCD3B ( ortholog_one2one ) GuineaPig_ TLCD3B ( ortholog_one2one ) Macaque_ TLCD3B ( ortholog_one2one ) Mouse_ Tlcd3b ( ortholog_one2one ) Pig_ TLCD3B ( ortholog_one2one ) Rat_ Tlcd3b ( ortholog_one2one ) |
| Ohnologs | TLCD3A |
| Paralogs | TLCD3A, TLCD4, TLCD2, TLCD1, CLN8 |
| Tissue | testis, adipose.tissue, adrenal.gland, brain, heart, kidney, liver, lung, ovary, pancreas, sigmoid.colon, small.intestine, spleen, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Expressed in testis (PubMed:33077892). Expressed in the retina with higher expression levels in the macular than in the peripheral region (PubMed:33077892). {ECO:0000269|PubMed:33077892}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q7TNV1}; Multi-pass membrane protein {ECO:0000255}.; [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7TNV1}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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