| Gene Information | |
|---|---|
| Gene Name | SIRPB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 398 |
| Protein Names | Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000101307 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O00241 |
| Gene Card | SIRPB1 |
| Uniprot ID | O00241 |
| Pfam | PF07654; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.978745521) |
| Ortholog in Animals | Mouse_ Sirpb1a ( ortholog_many2many ) Mouse_ Sirpb1b ( ortholog_many2many ) Mouse_ Sirpb1c ( ortholog_many2many ) Mouse_ Sirpa ( ortholog_many2many ) Mouse_ Gm5150 ( ortholog_many2many ) Mouse_ Gm9733 ( ortholog_many2many ) Rat_ Sirpd ( ortholog_many2many ) Rat_ Sirpb2 ( ortholog_many2many ) Rat_ Sirpa ( ortholog_many2many ) Rat_ AABR07006142.1 ( ortholog_many2many ) Rat_ AABR07008876.1 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | SIRPA, SIRPG, SIRPD, SIRPB2 |
| Tissue | dura.mater, spleen, whole.blood |
| Tissue Specificity | Detected in monocytes and dendritic cells. {ECO:0000269|PubMed:10604985}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2D9C (NMR - ) 2JJU (X-ray 1.19A ) |
| DBSNP | rs1535882 rs2746603 rs2253427 rs2243603 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10604985}; Single-pass type I membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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