| Gene Information | |
|---|---|
| Gene Name | SIPL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | Sharpin (Shank-associated RH domain-interacting protein) (Shank-interacting protein-like 1) (hSIPL1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H0F6 |
| Gene Card | SHARPIN |
| Uniprot ID | Q9H0F6 |
| Pfam | PF16764 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. Up-regulated in various tumor tissues such as kidney, liver, ovary and pancreas tumors. {ECO:0000269|PubMed:20179993}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4EMO (X-ray 2.00A ) 5X0W (X-ray 3.00A ) |
| DBSNP | rs11541804 rs34674752 rs35844464 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:20179993}. Synapse {ECO:0000250|UniProtKB:Q9EQL9}. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1. {ECO:0000250|UniProtKB:Q9EQL9}. |
| Mouse PG classification | NA |
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