| Gene Information | |
|---|---|
| Gene Name | CDKL5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 960 |
| Protein Names | Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000008086 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O76039 |
| Gene Card | CDKL5 |
| Uniprot ID | O76039 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.132857058) |
| Ortholog in Animals | Alpaca_ CDKL5 ( ortholog_one2one ) Dog_ CDKL5 ( ortholog_one2one ) GuineaPig_ CDKL5 ( ortholog_one2one ) Macaque_ CDKL5 ( ortholog_one2one ) Mouse_ Cdkl5 ( ortholog_one2one ) Pig_ CDKL5 ( ortholog_one2one ) Rat_ Cdkl5 ( ortholog_one2one ) Rabbit_ CDKL5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDK14, CDKL2, CDK5, CDKL3, CDK7, CDK3, CDK1, CDKL1, CDK19, CDK6, CDK16, CDK15, CDK4, CDKL4, CDK2, CDK20, CDK9, CDK12, CDK8, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.; [Isoform 2]: Predominant transcript in brain. {ECO:0000269|PubMed:21748340}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BGQ (X-ray 2.00A ) |
| DBSNP | rs122460159 rs62641235 rs62641235 rs267608468 rs122460157 rs61749700 rs267606715 rs267606715 rs267608493 rs61749704 rs267608501 rs267608511 rs267606713 rs267606714 rs267608611 rs61753977 rs199897804 rs267608653 rs55803460 rs35478150 rs62643617 rs773760466 rs267608664 rs866859766 rs35693326 rs34166184 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16935860}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29420175}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29420175}. |
| Mouse PG classification | LPG |
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