| Gene Information | |
|---|---|
| Gene Name | SIM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 667 |
| Protein Names | Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000159263 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14190 |
| Gene Card | SIM2 |
| Uniprot ID | Q14190 |
| Pfam | PF00989; PF08447; PF06621 |
| In ASD | no |
| Allosteric Prediction | no (-0.300820107) |
| Ortholog in Animals | Alpaca_ SIM2 ( ortholog_one2one ) Dog_ SIM2 ( ortholog_one2one ) GuineaPig_ SIM2 ( ortholog_one2one ) Macaque_ SIM2 ( ortholog_one2one ) Mouse_ Sim2 ( ortholog_one2one ) Pig_ SIM2 ( ortholog_one2one ) Rat_ Sim2 ( ortholog_one2one ) Rabbit_ SIM2 ( ortholog_one2one ) |
| Ohnologs | SIM1, NPAS1 |
| Paralogs | EPAS1, SIM1, NPAS1, NPAS4, HIF1A, NPAS3, HIF3A |
| Tissue | esophagus, kidney |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2073601 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:14697214}. |
| Mouse PG classification | NA |
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