| Gene Information | |
|---|---|
| Gene Name | SIL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 461 |
| Protein Names | Nucleotide exchange factor SIL1 (BiP-associated protein) (BAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000120725 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H173 |
| Gene Card | SIL1 |
| Uniprot ID | Q9H173 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.885832178) |
| Ortholog in Animals | Alpaca_ SIL1 ( ortholog_one2one ) Dog_ SIL1 ( ortholog_one2one ) GuineaPig_ SIL1 ( ortholog_one2one ) Macaque_ SIL1 ( ortholog_one2one ) Mouse_ Sil1 ( ortholog_one2one ) Pig_ SIL1 ( ortholog_one2one ) Rat_ Sil1 ( ortholog_one2one ) Rabbit_ SIL1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HSPBP1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain. {ECO:0000269|PubMed:12356756, ECO:0000269|PubMed:16282978}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6LBN (X-ray 2.90A ) 6LEY (X-ray 2.39A ) |
| DBSNP | rs35581768 |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000269|PubMed:12356756, ECO:0000269|PubMed:16282978}. |
| Mouse PG classification | NA |
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