| Gene Information | |
|---|---|
| Gene Name | SIGLEC15 |
| Organism | Homo sapiens (Human) |
| Gene Length | 328 |
| Protein Names | Sialic acid-binding Ig-like lectin 15 (Siglec-15) (CD33 antigen-like 3) |
| Target Name | sialic acid-binding immunoglobulin-like lectin 15 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000197046 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6ZMC9 |
| Gene Card | SIGLEC15 |
| Uniprot ID | Q6ZMC9 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.898926469) |
| Ortholog in Animals | Alpaca_ SIGLEC15 ( ortholog_one2one ) Dog_ SIGLEC15 ( ortholog_one2one ) Macaque_ SIGLEC15 ( ortholog_one2one ) Mouse_ Siglec15 ( ortholog_one2one ) Pig_ SIGLEC15 ( ortholog_one2one ) Rat_ Siglec15 ( ortholog_one2one ) Rabbit_ SIGLEC15 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAG, SIGLECL1, CD22, SIGLEC1, SIGLEC5, SIGLEC7, SIGLEC11, SIGLEC8, CD33, SIGLEC9, SIGLEC12, SIGLEC16, SIGLEC10, SIGLEC14, SIGLEC6, TMEM25 |
| Tissue | NA |
| Tissue Specificity | Expressed in macrophage and/or dendritic cells of spleen and lymph nodes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2919643 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |