| Gene Information | |
|---|---|
| Gene Name | SIGIRR |
| Organism | Homo sapiens (Human) |
| Gene Length | 410 |
| Protein Names | Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000185187 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6IA17 |
| Gene Card | SIGIRR |
| Uniprot ID | Q6IA17 |
| Pfam | PF01582 |
| In ASD | no |
| Allosteric Prediction | no (-0.999571557) |
| Ortholog in Animals | Alpaca_ SIGIRR ( ortholog_one2one ) Dog_ SIGIRR ( ortholog_one2one ) GuineaPig_ SIGIRR ( ortholog_one2one ) Mouse_ Sigirr ( ortholog_one2one ) Pig_ SIGIRR ( ortholog_one2one ) Rat_ Sigirr ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL1R1, LAG3, IL18R1, IL1R2, IL1RL1, IL1RL2, IL18RAP, IL1RAP, IL1RAPL2, IL1RAPL1 |
| Tissue | NA |
| Tissue Specificity | Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:21077278}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs117739035 rs111819059 rs3210908 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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