| Gene Information | |
|---|---|
| Gene Name | SHOX |
| Organism | Homo sapiens (Human) |
| Gene Length | 292 |
| Protein Names | Short stature homeobox protein (Pseudoautosomal homeobox-containing osteogenic protein) (Short stature homeobox-containing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000185960 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15266 |
| Gene Card | SHOX |
| Uniprot ID | O15266 |
| Pfam | PF00046; PF03826 |
| In ASD | no |
| Allosteric Prediction | no (-1.322342164) |
| Ortholog in Animals | Alpaca_ SHOX ( ortholog_one2one ) Dog_ SHOX ( ortholog_one2one ) Macaque_ SHOX ( ortholog_one2one ) Mouse_ Rhox10 ( ortholog_one2one ) Rat_ Rhox11 ( ortholog_one2many ) Rat_ Rhox10 ( ortholog_one2many ) |
| Ohnologs | SHOX2 |
| Paralogs | SHOX2, ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | NA |
| Tissue Specificity | SHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in brain, kidney, liver and lung. Highly expressed in osteogenic cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs137852554 rs137852555 rs137852557 rs137852556 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}. |
| Mouse PG classification | NA |
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