| Gene Information | |
|---|---|
| Gene Name | SHMT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) |
| Target Name | serine hydroxymethyltransferase, cytosolic |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000176974 ) 3 ( ENSG00000284320 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P34896 |
| Gene Card | SHMT1 |
| Uniprot ID | P34896 |
| Pfam | PF00464 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000210884) |
| Ortholog in Animals | Alpaca_ SHMT1 ( ortholog_one2one ) Dog_ SHMT1 ( ortholog_one2one ) GuineaPig_ SHMT1 ( ortholog_one2one ) Macaque_ SHMT1 ( ortholog_one2one ) Mouse_ Shmt1 ( ortholog_one2one ) Pig_ SHMT1 ( ortholog_one2one ) Rat_ Shmt1 ( ortholog_one2one ) Rabbit_ SHMT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SHMT2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BJ4 (X-ray 2.65A ) 6FL5 (X-ray 3.60A ) 6M5W (X-ray 3.10A ) 7RJL (X-ray 1.50A ) 7RJP (X-ray 1.25A ) |
| DBSNP | rs7215148 rs1979277 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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