| Gene Information | |
|---|---|
| Gene Name | SHLD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 835 |
| Protein Names | Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000122376 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86V20 |
| Gene Card | SHLD2 |
| Uniprot ID | Q86V20 |
| Pfam | PF15793 |
| In ASD | no |
| Allosteric Prediction | no (-0.789110581) |
| Ortholog in Animals | Alpaca_ SHLD2 ( ortholog_one2one ) GuineaPig_ SHLD2 ( ortholog_one2one ) Macaque_ SHLD2 ( ortholog_one2one ) Mouse_ Shld2 ( ortholog_one2one ) Pig_ SHLD2 ( ortholog_one2one ) Rat_ Shld2 ( ortholog_one2one ) Rabbit_ SHLD2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6KTO (X-ray 3.45A ) 6WWA (X-ray 3.80A ) 7L9P (EM 3.60A ) |
| DBSNP | rs3129520 rs11202365 rs11816168 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}. Chromosome {ECO:0000269|PubMed:29656893, ECO:0000305|PubMed:29789392}. Note=Localizes to nuclear foci in response to DNA damage. {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}. |
| Mouse PG classification | NA |
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