Gene Information
Gene NameSHH
OrganismHomo sapiens (Human)
Gene Length462
Protein NamesSonic hedgehog protein (SHH) (EC 3.1.-.-) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000164690 )
Evolutionary StageEumetazoa
AlphaFoldDBQ15465
Gene CardSHH
Uniprot IDQ15465
PfamPF01085; PF01079
In ASDno
Allosteric Predictionyes (0.321093163)
Ortholog in AnimalsAlpaca_ SHH ( ortholog_one2one )
Dog_ SHH ( ortholog_one2one )
GuineaPig_ SHH ( ortholog_one2one )
Macaque_ SHH ( ortholog_one2one )
Mouse_ Shh ( ortholog_one2one )
Pig_ SHH ( ortholog_one2one )
Rat_ Shh ( ortholog_one2one )
Rabbit_ SHH ( ortholog_one2one )
OhnologsDHH, IHH
ParalogsDHH, IHH
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.005990(Rat);0.033333(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3HO5  (X-ray  3.01A  )  3M1N  (X-ray  1.85A  )  3MXW  (X-ray  1.83A  )  6DMY  (EM  3.60A  )  6E1H  (EM  3.50A  )  6N7G  (EM  6.80A  )  6N7H  (EM  3.60A  )  6N7K  (EM  6.50A  )  6OEV  (EM  3.80A  )  6PJV  (X-ray  1.43A  )  6RMG  (EM  3.40A  )  6RVD  (EM  3.50A  )  7E2I  (EM  4.07A  )  7MHZ  (EM  3.20A  )  7RHQ  (EM  3.53A  ) 
DBSNP rs28936675  rs1428916820  rs104894050  rs587778792  rs104894049  rs267607047  rs104894040  rs104894040  rs1554494372  rs587778799  rs752650571  rs587778805  rs104894042  rs104894043  rs1347054935  rs587778806  rs556192490  rs104894047  rs955894039  rs104894052  rs886042458  rs886042458  rs137853341  rs1131692264  rs1412744230  rs104894048 
Subcellular location [CC][Sonic hedgehog protein]: Endoplasmic reticulum membrane {ECO:0000305|PubMed:18534984}. Golgi apparatus membrane {ECO:0000305|PubMed:18534984}. Secreted {ECO:0000269|PubMed:24342078}. Note=Co-localizes with HHAT in the ER and Golgi membrane. {ECO:0000305|PubMed:18534984}.;
[Sonic hedgehog protein N-product]: Cell membrane {ECO:0000250|UniProtKB:Q62226};
Lipid-anchor {ECO:0000250|UniProtKB:Q62226}. Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides (PubMed:26875496, PubMed:24522195). {ECO:0000305|PubMed:24522195, ECO:0000305|PubMed:26875496}.
Mouse PG classificationHPG
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