| Gene Information | |
|---|---|
| Gene Name | SHC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 630 |
| Protein Names | SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000185634 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q6S5L8 |
| Gene Card | SHC4 |
| Uniprot ID | Q6S5L8 |
| Pfam | PF00640; PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.620901916) |
| Ortholog in Animals | Alpaca_ SHC4 ( ortholog_one2one ) Dog_ SHC4 ( ortholog_one2one ) Macaque_ SHC4 ( ortholog_one2one ) Mouse_ Shc4 ( ortholog_one2one ) Pig_ SHC4 ( ortholog_one2one ) Rat_ Shc4 ( ortholog_one2one ) Rabbit_ SHC4 ( ortholog_one2one ) |
| Ohnologs | SHC2, SHC3, SHC1 |
| Paralogs | SHC1, SHC3, CEP152 |
| Tissue | brain, testis, tibial.nerve |
| Tissue Specificity | Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. {ECO:0000269|PubMed:17409413}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.025000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs17856991 rs17856990 rs16961728 rs17856992 |
| Subcellular location [CC] | Postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}. |
| Mouse PG classification | NA |
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