| Gene Information | |
|---|---|
| Gene Name | SHC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 583 |
| Protein Names | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000160691 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P29353 |
| Gene Card | SHC1 |
| Uniprot ID | P29353 |
| Pfam | PF00640; PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (1.182906454) |
| Ortholog in Animals | Alpaca_ SHC1 ( ortholog_one2one ) Dog_ SHC1 ( ortholog_one2one ) GuineaPig_ SHC1 ( ortholog_one2one ) Macaque_ SHC1 ( ortholog_one2one ) Mouse_ Shc1 ( ortholog_one2one ) Pig_ SHC1 ( ortholog_one2one ) Rat_ Shc1 ( ortholog_one2one ) Rabbit_ SHC1 ( ortholog_one2one ) |
| Ohnologs | SHC2, SHC3, SHC4 |
| Paralogs | SHC4, SHC3, CEP152 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in neural stem cells but absent in mature neurons. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002797(Rat);0.034091(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1MIL (X-ray 2.70A ) 1N3H (NMR - ) 1OY2 (NMR - ) 1QG1 (NMR - ) 1SHC (NMR - ) 1TCE (NMR - ) 2L1C (NMR - ) 4JMH (X-ray 2.41A ) 4XWX (X-ray 1.87A ) 5CZI (X-ray 2.60A ) 6DM4 (X-ray 1.90A ) |
| DBSNP | rs8191981 rs8191979 |
| Subcellular location [CC] | Cytoplasm.; [Isoform p46Shc]: Mitochondrion matrix {ECO:0000269|PubMed:14573619}. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; [Isoform p66Shc]: Mitochondrion {ECO:0000250}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}. |
| Mouse PG classification | NA |
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