| Gene Information | |
|---|---|
| Gene Name | SHBG |
| Organism | Homo sapiens (Human) |
| Gene Length | 402 |
| Protein Names | Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin) |
| Target Name | sex hormone-binding globulin |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000129214 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P04278 |
| Gene Card | SHBG |
| Uniprot ID | P04278 |
| Pfam | PF00054 |
| In ASD | yes |
| Allosteric Prediction | yes (0.809049469) |
| Ortholog in Animals | Alpaca_ SHBG ( ortholog_one2one ) Dog_ SHBG ( ortholog_one2one ) GuineaPig_ SHBG ( ortholog_one2one ) Macaque_ SHBG ( ortholog_one2one ) Mouse_ Shbg ( ortholog_one2one ) Rat_ Shbg ( ortholog_one2one ) Rabbit_ SHBG ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PROS1 |
| Tissue | liver |
| Tissue Specificity | Isoform 1 and isoform 2 are present in liver and testis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1D2S (X-ray 1.55A ) 1F5F (X-ray 1.70A ) 1KDK (X-ray 1.70A ) 1KDM (X-ray 2.35A ) 1LHN (X-ray 2.00A ) 1LHO (X-ray 2.00A ) 1LHU (X-ray 1.80A ) 1LHV (X-ray 2.00A ) 1LHW (X-ray 1.75A ) 6PYA (X-ray 1.71A ) 6PYB (X-ray 1.80A ) 6PYF (X-ray 1.73A ) 6ULB (X-ray 1.75A ) |
| DBSNP | rs9282845 rs6260 rs6258 rs6259 |
| Subcellular location [CC] | Secreted {ECO:0000250}. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}. |
| Mouse PG classification | NA |
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