| Gene Information | |
|---|---|
| Gene Name | HLA-E |
| Organism | Homo sapiens (Human) |
| Gene Length | 358 |
| Protein Names | HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000204592 ) 3 ( ENSG00000206493 ) 3 ( ENSG00000225201 ) 3 ( ENSG00000229252 ) 3 ( ENSG00000230254 ) 3 ( ENSG00000233904 ) 3 ( ENSG00000236632 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P13747 |
| Gene Card | HLA-E |
| Uniprot ID | P13747 |
| Pfam | PF07654; PF00129; PF06623 |
| In ASD | no |
| Allosteric Prediction | no (-0.350767277) |
| Ortholog in Animals | Alpaca_ PATR-E ( ortholog_one2one ) Macaque_ HLA-E ( ortholog_one2one ) Mouse_ H2-M10.6 ( ortholog_many2many ) Mouse_ H2-M10.4 ( ortholog_many2many ) Mouse_ H2-M1 ( ortholog_many2many ) Mouse_ H2-D1 ( ortholog_many2many ) Mouse_ H2-Q1 ( ortholog_many2many ) Mouse_ H2-T3 ( ortholog_many2many ) Mouse_ H2-Q2 ( ortholog_many2many ) Mouse_ H2-Q4 ( ortholog_many2many ) Mouse_ Gm8909 ( ortholog_many2many ) Mouse_ H2-Q7 ( ortholog_many2many ) Mouse_ H2-M11 ( ortholog_many2many ) Mouse_ H2-Q10 ( ortholog_many2many ) Mouse_ H2-M10.1 ( ortholog_many2many ) Mouse_ Gm11127 ( ortholog_many2many ) Mouse_ H2-M9 ( ortholog_many2many ) Mouse_ H2-T23 ( ortholog_many2many ) Mouse_ H2-M5 ( ortholog_many2many ) Mouse_ H2-M3 ( ortholog_many2many ) Mouse_ H2-M10.3 ( ortholog_many2many ) Mouse_ H2-M10.2 ( ortholog_many2many ) Mouse_ H2-Q6 ( ortholog_many2many ) Mouse_ H2-T22 ( ortholog_many2many ) Mouse_ H2-M10.5 ( ortholog_many2many ) Mouse_ Gm7030 ( ortholog_many2many ) Mouse_ H2-T10 ( ortholog_many2many ) Mouse_ H2-M2 ( ortholog_many2many ) Mouse_ 2410137M14Rik ( ortholog_many2many ) Mouse_ H2-K1 ( ortholog_many2many ) Rat_ AABR07072807.1 ( ortholog_many2many ) Rat_ RT1-S2 ( ortholog_many2many ) Rat_ RT1-M1-4 ( ortholog_many2many ) Rat_ RT1-CE16 ( ortholog_many2many ) Rat_ RT1-S3 ( ortholog_many2many ) Rat_ AABR07044308.2 ( ortholog_many2many ) Rat_ RT1-M1-2 ( ortholog_many2many ) Rat_ AABR07044383.1 ( ortholog_many2many ) Rat_ AABR07044308.1 ( ortholog_many2many ) Rat_ RT1-M3-1 ( ortholog_many2many ) Rat_ RT1-CE14 ( ortholog_many2many ) Rat_ RT1-CE11 ( ortholog_many2many ) Rat_ RT1-N3 ( ortholog_many2many ) Rat_ RT1-CE2 ( ortholog_many2many ) Rat_ RT1-CE1 ( ortholog_many2many ) Rat_ AABR07044397.1 ( ortholog_many2many ) Rat_ AABR07044362.1 ( ortholog_many2many ) Rat_ RT1-M2 ( ortholog_many2many ) Rat_ RT1-M6-2 ( ortholog_many2many ) Rat_ RT1-M5 ( ortholog_many2many ) Rat_ RT1-M10-1 ( ortholog_many2many ) Rat_ RT1-N2 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | MR1, AZGP1, MICA, HFE, MICB, CD1B, ULBP2, RAET1L, FCGRT, RAET1G, CD1A, CD1D, CD1C, RAET1E, ULBP3, ULBP1, CD1E, HLA-B, HLA-A, HLA-F, HLA-G, HLA-C |
| Tissue | NA |
| Tissue Specificity | Expressed in secretory endometrial cells during pregnancy (at protein level). The expression in nonlymphoid tissues is restricted to endothelial cells from all types of vessels, including arteries, veins, capillaries, and lymphatics (at protein level). In lymphoid organs, it is mainly expressed in endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (at protein level). {ECO:0000269|PubMed:17179229}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1KPR (X-ray 2.80A ) 1KTL (X-ray 3.10A ) 1MHE (X-ray 2.85A ) 2ESV (X-ray 2.60A ) 3AM8 (X-ray 2.80A ) 3BZE (X-ray 2.50A ) 3BZF (X-ray 2.50A ) 3CDG (X-ray 3.40A ) 3CII (X-ray 4.41A ) 5W1V (X-ray 3.31A ) 5W1W (X-ray 3.10A ) 6GGM (X-ray 2.73A ) 6GH1 (X-ray 2.10A ) 6GH4 (X-ray 2.16A ) 6GHN (X-ray 2.54A ) 6GL1 (X-ray 2.62A ) 6ZKW (X-ray 2.26A ) 6ZKX (X-ray 2.17A ) 6ZKY (X-ray 2.65A ) 6ZKZ (X-ray 2.30A ) 7BH8 (X-ray 1.80A ) 7NDQ (X-ray 2.55A ) 7NDT (X-ray 3.00A ) 7NDU (X-ray 2.90A ) 7P49 (X-ray 2.05A ) 7P4B (X-ray 1.72A ) |
| DBSNP | rs1059510 rs1264457 rs41562314 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:9427624}; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000269|PubMed:17179229}.; [Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted {ECO:0000269|PubMed:17179229}. |
| Mouse PG classification | NA |
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