Gene Information
Gene NameSH3RF1
OrganismHomo sapiens (Human)
Gene Length888
Protein NamesE3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000154447 )
Evolutionary StageEumetazoa
AlphaFoldDBQ7Z6J0
Gene CardSH3RF1
Uniprot IDQ7Z6J0
PfamPF00018; PF14604
In ASDno
Allosteric Predictionno (-0.776539098)
Ortholog in AnimalsAlpaca_ SH3RF1 ( ortholog_one2one )
Dog_ SH3RF1 ( ortholog_one2one )
GuineaPig_ SH3RF1 ( ortholog_one2one )
Macaque_ SH3RF1 ( ortholog_one2one )
Mouse_ Sh3rf1 ( ortholog_one2one )
Pig_ SH3RF1 ( ortholog_one2one )
Rat_ Sh3rf1 ( ortholog_one2one )
Rabbit_ SH3RF1 ( ortholog_one2one )
OhnologsSH3RF2, SH3RF3
ParalogsSH3GL3, SORBS1, SORBS2, SH3GLB1, SORBS3, SH3GLB2, NCF4, SH3RF3, SH3RF2, SH3GL1, SH3D19, SH3GL2
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7NZC  (X-ray  1.11A  7NZD  (X-ray  1.45A 
DBSNP rs3811813 
Subcellular location [CC]Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q71F54}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q69ZI1}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:15659549, ECO:0000269|PubMed:17420289}. Note=Colocalizes, with AKT2, in lamellipodia (By similarity). Colocalizes, with HERP1, in trans-Golgi network. {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:17420289}.
Mouse PG classificationNA
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