| Gene Information | |
|---|---|
| Gene Name | IL21R |
| Organism | Homo sapiens (Human) |
| Gene Length | 538 |
| Protein Names | Interleukin-21 receptor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD antigen CD360) |
| Target Name | interleukin 21 receptor |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000103522 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9HBE5 |
| Gene Card | IL21R |
| Uniprot ID | Q9HBE5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.459512188) |
| Ortholog in Animals | Alpaca_ IL21R ( ortholog_one2one ) Dog_ IL21R ( ortholog_one2one ) GuineaPig_ IL21R ( ortholog_one2one ) Macaque_ IL21R ( ortholog_one2one ) Mouse_ Il21r ( ortholog_one2one ) Pig_ IL21R ( ortholog_one2one ) Rat_ Il21r ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MPL, IL4R, IL2RB, IL7R, IL9R, CSF2RB, EPOR |
| Tissue | lymph.node, appendix, tonsil |
| Tissue Specificity | Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3TGX (X-ray 2.80A ) 4NZD (X-ray 2.75A ) 6PLH (X-ray 1.60A ) 7KQ7 (X-ray 2.20A ) |
| DBSNP | rs3093370 rs397514685 rs3093385 rs3093386 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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