Gene Information
Gene NameCAPN1
OrganismHomo sapiens (Human)
Gene Length714
Protein NamesCalpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
Target Namecalpain-1
Target TypePatented-recorded target
Gene Age1488 ( ENSG00000014216 )
Evolutionary StageEukaryota
AlphaFoldDBP07384
Gene CardCAPN1
Uniprot IDP07384
PfamPF01067; PF13833; PF00648
In ASDno
Allosteric Predictionyes (1.412826068)
Ortholog in AnimalsAlpaca_ CAPN1 ( ortholog_one2one )
Dog_ CAPN1 ( ortholog_one2one )
GuineaPig_ CAPN1 ( ortholog_one2one )
Macaque_ CAPN1 ( ortholog_one2one )
Mouse_ Capn1 ( ortholog_one2one )
Pig_ CAPN1 ( ortholog_one2one )
Rat_ Capn1 ( ortholog_one2one )
Rabbit_ CAPN1 ( ortholog_one2one )
OhnologsCAPN3, CAPN9, CAPN11, CAPN2
ParalogsPEF1, GCA, SRI, CAPN9, PDCD6, CAPN2, CAPN5, CAPN14, CAPN15, CAPN7, ADGB, CAPN6, CAPN8, CAPN3, CAPN12, CAPNS2, CAPN11, CAPN13, CAPNS1, CAPN10
TissueNA
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:2400579, ECO:0000269|PubMed:3017764, ECO:0000269|PubMed:8769305, ECO:0000269|PubMed:8954105, ECO:0000269|PubMed:9271093}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001490(Rat);0.02(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ZCM  (X-ray  2.00A  )  2ARY  (X-ray  2.40A  ) 
DBSNP rs17885718  rs756205995  rs10895991  rs17883283  rs17884773 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:8769305}. Cell membrane {ECO:0000269|PubMed:8769305}. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719). {ECO:0000269|PubMed:21531719}.
Mouse PG classificationLPG
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