| Gene Information | |
|---|---|
| Gene Name | SH3KBP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 665 |
| Protein Names | SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000147010 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96B97 |
| Gene Card | SH3KBP1 |
| Uniprot ID | Q96B97 |
| Pfam | PF14604 |
| In ASD | no |
| Allosteric Prediction | yes (0.142316133) |
| Ortholog in Animals | Alpaca_ SH3KBP1 ( ortholog_one2one ) Dog_ SH3KBP1 ( ortholog_one2one ) GuineaPig_ SH3KBP1 ( ortholog_one2one ) Macaque_ SH3KBP1 ( ortholog_one2one ) Mouse_ Sh3kbp1 ( ortholog_one2one ) Pig_ SH3KBP1 ( ortholog_one2one ) Rat_ Sh3kbp1 ( ortholog_one2one ) Rabbit_ SH3KBP1 ( ortholog_one2one ) |
| Ohnologs | CD2AP |
| Paralogs | CD2AP, NOSTRIN, SH3D21 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Also expressed in some cancer cell lines. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2BZ8 (X-ray 2.00A ) 2K6D (NMR - ) 2K9G (NMR - ) 2N64 (NMR - ) 2O2O (NMR - ) 2YDL (X-ray 2.05A ) 5ABS (X-ray 1.74A ) |
| DBSNP | rs1310665369 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20221403}. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403). {ECO:0000250|UniProtKB:Q8R550, ECO:0000269|PubMed:20221403}. |
| Mouse PG classification | NA |
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