Gene Information
Gene NameMKNK1
OrganismHomo sapiens (Human)
Gene Length465
Protein NamesMAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)
Target Namemapk signal-integrating kinase 1
Target TypeClinical trial target
Gene Age55 ( ENSG00000079277 )
Evolutionary StageEukaryota
AlphaFoldDBQ9BUB5
Gene CardMKNK1
Uniprot IDQ9BUB5
PfamPF00069
In ASDyes
Allosteric Predictionyes (0.897241067)
Ortholog in AnimalsAlpaca_ MKNK1 ( ortholog_one2one )
Dog_ MKNK1 ( ortholog_one2one )
Macaque_ MKNK1 ( ortholog_one2one )
Mouse_ Mknk1 ( ortholog_one2one )
Pig_ MKNK1 ( ortholog_one2one )
OhnologsMKNK2
ParalogsMAPKAPK3, MAPKAPK5, MAPKAPK2, MKNK2, CAMK4, DCX
TissueNA
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:15350534}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2HW6  (X-ray  2.50A  2Y9Q  (X-ray  1.55A  5WVD  (X-ray  3.00A 
DBSNP rs56351860  rs56408722  rs55791614  rs34881418 
Subcellular location [CC][Isoform 2]: Cytoplasm.;
[Isoform 3]: Cytoplasm. Nucleus.
Mouse PG classificationNA
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