| Gene Information | |
|---|---|
| Gene Name | SH2D3C |
| Organism | Homo sapiens (Human) |
| Gene Length | 860 |
| Protein Names | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000095370 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N5H7 |
| Gene Card | SH2D3C |
| Uniprot ID | Q8N5H7 |
| Pfam | PF00617; PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.072134185) |
| Ortholog in Animals | Alpaca_ SH2D3C ( ortholog_one2one ) Dog_ SH2D3C ( ortholog_one2one ) GuineaPig_ SH2D3C ( ortholog_one2one ) Macaque_ SH2D3C ( ortholog_one2one ) Mouse_ Sh2d3c ( ortholog_one2one ) Pig_ SH2D3C ( ortholog_one2one ) Rat_ Sh2d3c ( ortholog_one2one ) |
| Ohnologs | SH2D3A, BCAR3 |
| Paralogs | SH2D3A, BCAR3 |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Ubiquitously expressed. {ECO:0000269|PubMed:10187783}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.070650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3T6G (X-ray 2.50A ) |
| DBSNP | rs10760500 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17174122}. Cell membrane {ECO:0000269|PubMed:12432078}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QZS8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QZS8}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9QZS8}. Note=Associated with the membrane when EGF-stimulated (By similarity). Expressed at the cortical actin ring in B cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17174122}; Peripheral membrane protein {ECO:0000269|PubMed:17174122}. |
| Mouse PG classification | NA |
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