| Gene Information | |
|---|---|
| Gene Name | SH2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 756 |
| Protein Names | SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NRF2 |
| Gene Card | SH2B1 |
| Uniprot ID | Q9NRF2 |
| Pfam | PF00169; PF08916; PF00017 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in skeletal muscle and ovary. {ECO:0000269|PubMed:15767667}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5W3R (X-ray 1.39A ) |
| DBSNP | rs7498665 rs17850682 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}. |
| Mouse PG classification | NA |
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