Gene Information
Gene NameHSD17B7
OrganismHomo sapiens (Human)
Gene Length341
Protein Names3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1)
Target Name3-keto-steroid reductase
Target TypeNA
Gene Age680 ( ENSG00000132196 )
Evolutionary StageEuk+Bac
AlphaFoldDBP56937
Gene CardHSD17B7
Uniprot IDP56937
PfamPF00106
In ASDno
Allosteric Predictionyes (0.236748204)
Ortholog in AnimalsAlpaca_ HSD17B7 ( ortholog_one2one )
Alpaca_ HSD17B7 ( ortholog_one2many )
Dog_ HSD17B7 ( ortholog_one2one )
GuineaPig_ HSD17B7 ( ortholog_one2one )
Macaque_ HSD17B7 ( ortholog_one2one )
Mouse_ Hsd17b7 ( ortholog_one2one )
Pig_ HSD17B7 ( ortholog_one2one )
Rat_ Hsd17b7 ( ortholog_one2one )
OhnologsNA
ParalogsSDR9C7, HSD17B14, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, HSD17B2, RDH5, DHRS3, HSD17B13, HSD17B12, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6
TissueNA
Tissue SpecificityHighly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. {ECO:0000269|PubMed:12732193}.;
[Isoform 3]: Expressed in eye ciliary epithelial cells and neuroendocrine cells. {ECO:0000269|PubMed:12732193}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.04073(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:12829805};
Single-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
click here to return to the previous page