| Gene Information | |
|---|---|
| Gene Name | COTL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 142 |
| Protein Names | Coactosin-like protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000103187 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14019 |
| Gene Card | COTL1 |
| Uniprot ID | Q14019 |
| Pfam | PF00241 |
| In ASD | no |
| Allosteric Prediction | no (-0.288272958) |
| Ortholog in Animals | Alpaca_ COTL1 ( ortholog_one2one ) Dog_ COTL1 ( ortholog_one2one ) GuineaPig_ COTL1 ( ortholog_one2one ) Macaque_ COTL1 ( ortholog_one2one ) Mouse_ Cotl1 ( ortholog_one2one ) Pig_ COTL1 ( ortholog_one2one ) Rat_ Cotl1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HCLS1, CTTN, DBNL, DBN1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. {ECO:0000269|PubMed:11583571}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001615(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1T2L (X-ray 2.80A ) 1T3X (X-ray 2.00A ) 1T3Y (X-ray 1.15A ) 1TMW (NMR - ) 1VFQ (X-ray 1.90A ) 1WNJ (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11583571}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11583571}. Nucleus {ECO:0000269|PubMed:19807693}. |
| Mouse PG classification | NA |
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