| Gene Information | |
|---|---|
| Gene Name | SGOL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1265 |
| Protein Names | Shugoshin 2 (Shugoshin-2) (Shugoshin-like 2) (Tripin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q562F6 |
| Gene Card | SGO2 |
| Uniprot ID | Q562F6 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1036533 rs13417812 rs17448235 rs17532665 rs11896759 rs16833776 |
| Subcellular location [CC] | Nucleus {ECO:0000305|PubMed:17485487}. Chromosome, centromere {ECO:0000269|PubMed:17485487}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q7TSY8}. Note=During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity). SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity). During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487). Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487). {ECO:0000250|UniProtKB:Q7TSY8, ECO:0000269|PubMed:17485487}. |
| Mouse PG classification | NA |
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