| Gene Information | |
|---|---|
| Gene Name | SGCA |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | Alpha-sarcoglycan (Alpha-SG) (50 kDa dystrophin-associated glycoprotein) (50DAG) (Adhalin) (Dystroglycan-2) |
| Target Name | sarcoglycan alpha |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000108823 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q16586 |
| Gene Card | SGCA |
| Uniprot ID | Q16586 |
| Pfam | PF05510 |
| In ASD | no |
| Allosteric Prediction | no (-0.732796932) |
| Ortholog in Animals | Alpaca_ SGCA ( ortholog_one2one ) Dog_ SGCA ( ortholog_one2one ) GuineaPig_ SGCA ( ortholog_one2one ) Macaque_ SGCA ( ortholog_one2one ) Mouse_ Sgca ( ortholog_one2one ) Pig_ SGCA ( ortholog_one2one ) Rat_ Sgca ( ortholog_one2one ) Rabbit_ SGCA ( ortholog_one2one ) |
| Ohnologs | SGCE |
| Paralogs | SGCE |
| Tissue | heart |
| Tissue Specificity | Most strongly expressed in skeletal muscle. Also expressed in cardiac muscle and, at much lower levels, in lung. In the fetus, most abundant in cardiac muscle and, at lower levels, in lung. Also detected in liver and kidney. Not expressed in brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs886043256 rs903823830 rs758647756 rs371675217 rs757888349 rs1555568335 rs28933693 rs398123098 rs1435014211 rs1555568396 rs138945081 rs137852621 rs1161291343 rs768814872 rs397514451 rs372210292 rs143962150 rs137852622 rs752695991 rs757481230 rs1384158714 rs143570936 rs137852623 |
| Subcellular location [CC] | Cell membrane, sarcolemma {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. |
| Mouse PG classification | HPG |
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