| Gene Information | |
|---|---|
| Gene Name | SPAG4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 437 |
| Protein Names | Sperm-associated antigen 4 protein (Outer dense fiber-associated protein SPAG4) (SUN domain-containing protein 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000061656 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NPE6 |
| Gene Card | SPAG4 |
| Uniprot ID | Q9NPE6 |
| Pfam | PF07738 |
| In ASD | no |
| Allosteric Prediction | no (-0.537259548) |
| Ortholog in Animals | Alpaca_ SPAG4 ( ortholog_one2one ) Dog_ SPAG4 ( ortholog_one2one ) GuineaPig_ SPAG4 ( ortholog_one2one ) Macaque_ SPAG4 ( ortholog_one2one ) Mouse_ Spag4 ( ortholog_one2one ) Pig_ SPAG4 ( ortholog_one2one ) Rat_ Spag4 ( ortholog_one2one ) Rabbit_ SPAG4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SUN3, SUN5, SUN1, SUN2 |
| Tissue | NA |
| Tissue Specificity | Predominantly epressed in testis. Expressed in ejaculated spermatozoa (at protein level). {ECO:0000269|PubMed:25775403}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55034}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:O55034}. Nucleus envelope {ECO:0000250|UniProtKB:Q9JJF2}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q9JJF2}. Note=In spermatids, it is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity). Colocalized with SEPT12 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa (PubMed:25775403). {ECO:0000250|UniProtKB:O55034, ECO:0000269|PubMed:25775403}. |
| Mouse PG classification | NA |
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