| Gene Information | |
|---|---|
| Gene Name | PSENEN |
| Organism | Homo sapiens (Human) |
| Gene Length | 101 |
| Protein Names | Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2) |
| Target Name | gamma-secretase subunit pen-2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000205155 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZ42 |
| Gene Card | PSENEN |
| Uniprot ID | Q9NZ42 |
| Pfam | PF10251 |
| In ASD | no |
| Allosteric Prediction | no (-0.240930898) |
| Ortholog in Animals | Alpaca_ PSENEN ( ortholog_one2one ) Dog_ PSENEN ( ortholog_one2one ) GuineaPig_ PSENEN ( ortholog_one2one ) Macaque_ PSENEN ( ortholog_one2one ) Mouse_ Psenen ( ortholog_one2one ) Pig_ PSENEN ( ortholog_one2one ) Rat_ Psenen ( ortholog_one2one ) Rabbit_ PSENEN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12110170, ECO:0000269|PubMed:12740439}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.278549(Rat);0.381934(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5A63 (EM 3.40A ) 5FN2 (EM 4.20A ) 5FN3 (EM 4.10A ) 5FN4 (EM 4.00A ) 5FN5 (EM 4.30A ) 6IDF (EM 2.70A ) 6IYC (EM 2.60A ) 6LQG (EM 3.10A ) 6LR4 (EM 3.00A ) 7C9I (EM 3.10A ) 7D8X (EM 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12639958}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12639958}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Cell membrane {ECO:0000269|PubMed:24941111}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517}. Membrane {ECO:0000269|PubMed:12198112}; Multi-pass membrane protein {ECO:0000269|PubMed:12639958, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:26623517, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000269|PubMed:12639958}. |
| Mouse PG classification | NA |
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