| Gene Information | |
|---|---|
| Gene Name | SPRED1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000166068 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z699 |
| Gene Card | SPRED1 |
| Uniprot ID | Q7Z699 |
| Pfam | PF05210; PF00568 |
| In ASD | no |
| Allosteric Prediction | no (-0.66284382) |
| Ortholog in Animals | Alpaca_ SPRED1 ( ortholog_one2one ) Dog_ SPRED1 ( ortholog_one2one ) GuineaPig_ SPRED1 ( ortholog_one2one ) Macaque_ SPRED1 ( ortholog_one2one ) Mouse_ Spred1 ( ortholog_one2one ) Pig_ SPRED1 ( ortholog_one2one ) Rat_ Spred1 ( ortholog_one2one ) Rabbit_ SPRED1 ( ortholog_one2one ) |
| Ohnologs | SPRED2 |
| Paralogs | SPRED3, VASP, ENAH, SPRED2, EVL |
| Tissue | NA |
| Tissue Specificity | Weakly expressed in embryonic cell line HEK293. {ECO:0000269|PubMed:15580519}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3SYX (X-ray 2.45A ) 6V65 (X-ray 2.76A ) 6V6F (X-ray 2.54A ) |
| DBSNP | rs121434318 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Membrane, caveola {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Nucleus {ECO:0000269|PubMed:16115197}. Note=Localized in cholesterol-rich membrane raft/caveola fractions. |
| Mouse PG classification | NA |
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