| Gene Information | |
|---|---|
| Gene Name | LGALS8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000116977 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O00214 |
| Gene Card | LGALS8 |
| Uniprot ID | O00214 |
| Pfam | PF00337 |
| In ASD | no |
| Allosteric Prediction | no (-0.498945992) |
| Ortholog in Animals | Alpaca_ LGALS8 ( ortholog_one2one ) Dog_ LGALS8 ( ortholog_one2one ) GuineaPig_ LGALS8 ( ortholog_one2one ) Macaque_ LGALS8 ( ortholog_one2one ) Mouse_ Lgals8 ( ortholog_one2one ) Pig_ LGALS8 ( ortholog_one2one ) Rat_ Lgals8 ( ortholog_one2one ) Rabbit_ LGALS8 ( ortholog_one2one ) |
| Ohnologs | LGALS12, LGALS4 |
| Paralogs | LGALSL, GRIFIN, LGALS7, LGALS7B, LGALS3, LGALS1, LGALS4, LGALS12, LGALS2, LGALS13, LGALS14, LGALS16, LGALS9B, LGALS9, LGALS9C, CLC |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YRO (NMR - ) 2YV8 (X-ray 1.92A ) 2YXS (X-ray 2.13A ) 3AP4 (X-ray 2.33A ) 3AP5 (X-ray 1.92A ) 3AP6 (X-ray 1.58A ) 3AP7 (X-ray 1.53A ) 3AP9 (X-ray 1.33A ) 3APB (X-ray 1.95A ) 3OJB (X-ray 3.01A ) 3VKL (X-ray 2.55A ) 3VKM (X-ray 2.98A ) 3VKN (X-ray 1.98A ) 3VKO (X-ray 2.08A ) 4BMB (X-ray 1.35A ) 4BME (X-ray 2.00A ) 4FQZ (X-ray 2.80A ) 4GXL (X-ray 2.02A ) 4HAN (X-ray 2.55A ) 5GZC (X-ray 1.08A ) 5GZD (X-ray 1.19A ) 5GZE (X-ray 1.32A ) 5GZF (X-ray 2.00A ) 5GZG (X-ray 2.00A ) 5T7I (X-ray 2.00A ) 5T7S (X-ray 1.90A ) 5T7T (X-ray 1.96A ) 5T7U (X-ray 1.58A ) 5VWG (X-ray 2.10A ) 6W4Z (X-ray 1.59A ) 6Z6Y (X-ray 1.34A ) 7AEN (X-ray 1.60A ) 7ALS (X-ray 1.35A ) 7P1M (X-ray 1.52A ) |
| DBSNP | rs1126407 rs1041935 rs1041937 rs2243525 |
| Subcellular location [CC] | Cytoplasmic vesicle {ECO:0000269|PubMed:22246324}. Cytoplasm, cytosol {ECO:0000269|PubMed:22246324}. |
| Mouse PG classification | NA |
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