Gene Information
Gene NameSREBP1
OrganismHomo sapiens (Human)
Gene Length1147
Protein NamesSterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP36956
Gene CardSREBF1
Uniprot IDP36956
PfamPF00010
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in a wide variety of tissues, most abundant in liver and adrenal gland (PubMed:8402897). In fetal tissues lung and liver shows highest expression (PubMed:8402897). {ECO:0000269|PubMed:8402897}.;
[Isoform SREBP-1A]: Predominates in hepatoma cell lines (PubMed:8402897). Also expressed in kidney, brain, white fat, and muscle (PubMed:8402897). {ECO:0000269|PubMed:8402897}.;
[Isoform SREBP-1C]: Predominantly expressed in liver and adipose tissues (PubMed:8402897). Also expressed in kidney, brain, white fat, and muscle (PubMed:8402897). {ECO:0000269|PubMed:8402897}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002190(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AM9  (X-ray  2.30A  ) 
DBSNP rs17855793  rs35188700  rs2229590  rs2033690347  rs1428621525  rs2033688284  rs36215896  rs2228461  rs17855792  rs1042017  rs35014224 
Subcellular location [CC][Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038};
Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9WTN3};
Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9WTN3};
Multi-pass membrane protein {ECO:0000255}. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed. {ECO:0000250|UniProtKB:Q9WTN3}.;
[Processed sterol regulatory element-binding protein 1]: Nucleus {ECO:0000269|PubMed:11477106, ECO:0000269|PubMed:32322062}.;
[Isoform SREBP-1aDelta]: Nucleus {ECO:0000269|PubMed:18267114, ECO:0000269|PubMed:32497488}.;
[Isoform SREBP-1cDelta]: Nucleus {ECO:0000269|PubMed:18267114, ECO:0000269|PubMed:32497488}.
Mouse PG classificationNA
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