| Gene Information | |
|---|---|
| Gene Name | SPAG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 926 |
| Protein Names | Sperm-associated antigen 1 (HSD-3.8) (Infertility-related sperm protein Spag-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000104450 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q07617 |
| Gene Card | SPAG1 |
| Uniprot ID | Q07617 |
| Pfam | PF13877; PF00515; PF13181 |
| In ASD | no |
| Allosteric Prediction | no (-1.287685627) |
| Ortholog in Animals | Alpaca_ SPAG1 ( ortholog_one2one ) Dog_ SPAG1 ( ortholog_one2one ) GuineaPig_ SPAG1 ( ortholog_one2one ) Macaque_ SPAG1 ( ortholog_one2one ) Mouse_ Spag1 ( ortholog_one2one ) Pig_ SPAG1 ( ortholog_one2one ) Rat_ Spag1 ( ortholog_one2one ) Rabbit_ SPAG1 ( ortholog_one2one ) |
| Ohnologs | TOMM34 |
| Paralogs | TTC1, TTC32, SUGT1, UNC45A, TTC4, TOMM34, SGTB, UNC45B, TOMM70, DNAAF4, TTC31, ST13, TTC12, STIP1, SPATA16, SGTA, RPAP3, STUB1 |
| Tissue | NA |
| Tissue Specificity | Present in most tissues, including lung, with the strongest expression in brain, colon, kidney, and testis. In sperm and testis, detected in particular in pachytene primary spermatocytes. Up-regulated in pancreatic tumor tissues and not in normal pancreatic tissue. {ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:1299558, ECO:0000269|PubMed:16983343, ECO:0000269|PubMed:24055112}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6I57 (NMR - ) 7BEV (NMR - ) |
| DBSNP | rs17335870 rs6511 rs6510 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11517287, ECO:0000269|PubMed:16983343}. Dynein axonemal particle {ECO:0000305}. Note=Colocalizes with tubulin. |
| Mouse PG classification | NA |
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