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Gene Information
Gene Name
SFN
Organism
Homo sapiens (Human)
Gene Length
248
Protein Names
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Target Name
NA
Target Type
NA
Gene Age
424 ( ENSG00000175793 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P31947
Gene Card
SFN
Uniprot ID
P31947
Pfam
PF00244
In ASD
no
Allosteric Prediction
yes (0.505002236)
Ortholog in Animals
Alpaca_ SFN ( ortholog_one2one )
GuineaPig_ SFN ( ortholog_one2one )
Macaque_ SFN ( ortholog_one2one )
Mouse_ Sfn ( ortholog_one2one )
Pig_ SFN ( ortholog_one2one )
Rat_ Sfn ( ortholog_one2many )
Ohnologs
YWHAH, YWHAQ, YWHAZ, YWHAB, YWHAG
Paralogs
YWHAZ, YWHAE, YWHAB, YWHAQ, YWHAH, YWHAG
Tissue
tongue, esophagus.mucosa, suprapubic.skin
Tissue Specificity
Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.001642(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1YWT
(X-ray
2.40A
)
1YZ5
(X-ray
2.80A
)
3IQJ
(X-ray
1.15A
)
3IQU
(X-ray
1.05A
)
3IQV
(X-ray
1.20A
)
3LW1
(X-ray
1.28A
)
3MHR
(X-ray
1.15A
)
3O8I
(X-ray
2.00A
)
3P1N
(X-ray
1.40A
)
3P1O
(X-ray
1.90A
)
3P1P
(X-ray
1.95A
)
3P1Q
(X-ray
1.70A
)
3P1R
(X-ray
1.70A
)
3P1S
(X-ray
1.65A
)
3SMK
(X-ray
2.10A
)
3SML
(X-ray
1.90A
)
3SMM
(X-ray
2.00A
)
3SMN
(X-ray
2.00A
)
3SMO
(X-ray
1.80A
)
3SP5
(X-ray
1.80A
)
3SPR
(X-ray
1.99A
)
3T0L
(X-ray
1.60A
)
3T0M
(X-ray
1.62A
)
3U9X
(X-ray
1.80A
)
3UX0
(X-ray
1.75A
)
4DAT
(X-ray
1.40A
)
4DAU
(X-ray
2.00A
)
4DHM
(X-ray
1.70A
)
4DHN
(X-ray
1.80A
)
4DHO
(X-ray
1.70A
)
4DHP
(X-ray
1.75A
)
4DHQ
(X-ray
1.75A
)
4DHR
(X-ray
1.40A
)
4DHS
(X-ray
1.74A
)
4DHT
(X-ray
1.80A
)
4DHU
(X-ray
1.67A
)
4FL5
(X-ray
1.90A
)
4FR3
(X-ray
1.90A
)
4IEA
(X-ray
1.70A
)
4JC3
(X-ray
2.05A
)
4JDD
(X-ray
2.10A
)
4QLI
(X-ray
1.45A
)
4Y32
(X-ray
1.70A
)
4Y3B
(X-ray
1.80A
)
4Y5I
(X-ray
1.40A
)
5BTV
(X-ray
1.70A
)
5HF3
(X-ray
1.80A
)
5LTW
(X-ray
4.50A
)
5LU1
(X-ray
2.40A
)
5LU2
(X-ray
2.50A
)
5MHC
(X-ray
1.20A
)
5MOC
(X-ray
1.80A
)
5MXO
(X-ray
1.20A
)
5MY9
(X-ray
1.33A
)
5MYC
(X-ray
1.46A
)
5N5R
(X-ray
1.80A
)
5N5T
(X-ray
1.80A
)
5N5W
(X-ray
1.37A
)
5N75
(X-ray
1.80A
)
5OEG
(X-ray
3.15A
)
5OEH
(X-ray
2.35A
)
5OK9
(X-ray
2.35A
)
5OKF
(X-ray
3.20A
)
5OM0
(X-ray
3.20A
)
5OMA
(X-ray
3.90A
)
6FAU
(X-ray
1.25A
)
6FAV
(X-ray
1.40A
)
6FAW
(X-ray
1.40A
)
6FBB
(X-ray
1.30A
)
6FBW
(X-ray
1.45A
)
6FBY
(X-ray
1.50A
)
6FCP
(X-ray
1.45A
)
6FI4
(X-ray
2.00A
)
6FI5
(X-ray
1.70A
)
6G6X
(X-ray
1.13A
)
6G8I
(X-ray
1.60A
)
6G8J
(X-ray
1.47A
)
6G8K
(X-ray
1.25A
)
6G8L
(X-ray
1.37A
)
6G8P
(X-ray
1.90A
)
6G8Q
(X-ray
1.85A
)
6GHP
(X-ray
1.95A
)
6HHP
(X-ray
1.80A
)
6HKB
(X-ray
1.70A
)
6HKF
(X-ray
1.80A
)
6HMT
(X-ray
1.10A
)
6HMU
(X-ray
1.20A
)
6HN2
(X-ray
1.70A
)
6NV2
(X-ray
1.13A
)
6QDR
(X-ray
1.61A
)
6QDS
(X-ray
1.72A
)
6QDT
(X-ray
1.70A
)
6QDU
(X-ray
1.63A
)
6QHL
(X-ray
1.20A
)
6QHM
(X-ray
1.25A
)
6QIU
(X-ray
1.80A
)
6QZR
(X-ray
2.30A
)
6QZS
(X-ray
1.90A
)
6R5L
(X-ray
1.88A
)
6RHC
(X-ray
1.20A
)
6RJL
(X-ray
1.28A
)
6RJQ
(X-ray
1.89A
)
6RJZ
(X-ray
1.58A
)
6RK8
(X-ray
1.60A
)
6RKI
(X-ray
1.88A
)
6RKK
(X-ray
1.88A
)
6RKM
(X-ray
1.88A
)
6RL3
(X-ray
1.30A
)
6RL4
(X-ray
1.60A
)
6RL6
(X-ray
1.60A
)
6RM5
(X-ray
1.88A
)
6RM7
(X-ray
1.60A
)
6RP6
(X-ray
1.89A
)
6RWH
(X-ray
1.68A
)
6RWI
(X-ray
1.65A
)
6RWS
(X-ray
1.53A
)
6RWU
(X-ray
1.46A
)
6RX2
(X-ray
1.82A
)
6S39
(X-ray
1.88A
)
6S3C
(X-ray
2.00A
)
6S40
(X-ray
1.90A
)
6S9Q
(X-ray
1.69A
)
6SIN
(X-ray
1.64A
)
6SIO
(X-ray
1.60A
)
6SIP
(X-ray
1.60A
)
6SIQ
(X-ray
1.60A
)
6SLV
(X-ray
1.90A
)
6SLW
(X-ray
2.00A
)
6SLX
(X-ray
1.80A
)
6T5F
(X-ray
2.63A
)
6T5H
(X-ray
2.04A
)
6T80
(X-ray
2.99A
)
6TCH
(X-ray
1.80A
)
6TJM
(X-ray
1.85A
)
6TL3
(X-ray
2.46A
)
6TLF
(X-ray
2.90A
)
6TLG
(X-ray
2.40A
)
6TM7
(X-ray
3.00A
)
6TWZ
(X-ray
2.80A
)
6W0L
(X-ray
2.30A
)
6XWD
(X-ray
1.60A
)
6XXC
(X-ray
1.30A
)
6XY5
(X-ray
1.30A
)
6Y18
(X-ray
1.30A
)
6Y1D
(X-ray
1.38A
)
6Y1J
(X-ray
1.13A
)
6Y3M
(X-ray
1.50A
)
6Y3O
(X-ray
1.50A
)
6Y3R
(X-ray
1.50A
)
6Y3S
(X-ray
1.95A
)
6Y3V
(X-ray
1.50A
)
6Y3W
(X-ray
1.34A
)
6Y40
(X-ray
1.75A
)
6Y44
(X-ray
1.71A
)
6Y58
(X-ray
1.90A
)
6Y7T
(X-ray
2.50A
)
6Y8A
(X-ray
1.50A
)
6Y8B
(X-ray
1.54A
)
6Y8D
(X-ray
1.51A
)
6Y8E
(X-ray
1.42A
)
6YE9
(X-ray
1.80A
)
6YIA
(X-ray
1.30A
)
6YIB
(X-ray
1.70A
)
6YIC
(X-ray
1.60A
)
6YLU
(X-ray
1.88A
)
6YOW
(X-ray
1.23A
)
6YOX
(X-ray
2.05A
)
6YOY
(X-ray
1.80A
)
6YP2
(X-ray
1.80A
)
6YP3
(X-ray
1.80A
)
6YP8
(X-ray
1.80A
)
6YPL
(X-ray
1.80A
)
6YPY
(X-ray
1.40A
)
6YQ2
(X-ray
1.40A
)
6YR5
(X-ray
2.25A
)
6YR6
(X-ray
1.75A
)
6YR7
(X-ray
2.10A
)
6ZCJ
(X-ray
1.53A
)
6ZVB
(X-ray
2.51A
)
6ZVC
(X-ray
2.51A
)
6ZVD
(X-ray
2.50A
)
6ZVE
(X-ray
2.51A
)
7AEW
(X-ray
1.20A
)
7AOG
(X-ray
1.50A
)
7AXN
(X-ray
1.40A
)
7AYF
(X-ray
1.75A
)
7AZ1
(X-ray
1.15A
)
7AZ2
(X-ray
1.08A
)
7B13
(X-ray
1.37A
)
7B15
(X-ray
1.59A
)
7B9M
(X-ray
1.70A
)
7B9R
(X-ray
1.15A
)
7B9T
(X-ray
1.15A
)
7BA3
(X-ray
1.40A
)
7BA5
(X-ray
1.45A
)
7BA6
(X-ray
1.40A
)
7BA7
(X-ray
1.45A
)
7BA8
(X-ray
1.20A
)
7BA9
(X-ray
1.48A
)
7BAA
(X-ray
1.10A
)
7BAB
(X-ray
1.30A
)
7BDP
(X-ray
1.75A
)
7BDT
(X-ray
1.75A
)
7BDY
(X-ray
1.80A
)
7BFW
(X-ray
1.80A
)
7BG3
(X-ray
1.40A
)
7BGQ
(X-ray
1.75A
)
7BGR
(X-ray
1.80A
)
7BGV
(X-ray
1.68A
)
7BGW
(X-ray
1.90A
)
7BI3
(X-ray
1.20A
)
7BIQ
(X-ray
1.20A
)
7BIW
(X-ray
1.20A
)
7BIY
(X-ray
1.80A
)
7BJB
(X-ray
1.80A
)
7BJF
(X-ray
1.40A
)
7BJL
(X-ray
1.40A
)
7BJW
(X-ray
1.40A
)
7BKH
(X-ray
1.40A
)
7BM9
(X-ray
1.80A
)
7BMC
(X-ray
2.00A
)
7NFW
(X-ray
1.19A
)
7NIF
(X-ray
1.71A
)
7NIG
(X-ray
1.90A
)
7NIX
(X-ray
1.90A
)
7NIZ
(X-ray
1.48A
)
7NJ6
(X-ray
1.59A
)
7NJ8
(X-ray
1.80A
)
7NJ9
(X-ray
1.40A
)
7NJA
(X-ray
1.75A
)
7NJB
(X-ray
1.40A
)
7NK3
(X-ray
1.40A
)
7NK5
(X-ray
1.40A
)
7NLA
(X-ray
1.40A
)
7NLE
(X-ray
1.40A
)
7NM1
(X-ray
1.40A
)
7NM3
(X-ray
1.40A
)
7NM9
(X-ray
1.70A
)
7NMA
(X-ray
1.75A
)
7NMH
(X-ray
1.40A
)
7NMW
(X-ray
1.50A
)
7NMX
(X-ray
2.30A
)
7NN2
(X-ray
1.80A
)
7NND
(X-ray
1.40A
)
7NNE
(X-ray
1.96A
)
7NP2
(X-ray
1.27A
)
7NPB
(X-ray
1.37A
)
7NPG
(X-ray
1.37A
)
7NQP
(X-ray
1.24A
)
7NR7
(X-ray
1.40A
)
7NRK
(X-ray
1.75A
)
7NRL
(X-ray
1.80A
)
7NSV
(X-ray
1.33A
)
7NV4
(X-ray
1.20A
)
7NVI
(X-ray
1.20A
)
7NWS
(X-ray
1.20A
)
7NXS
(X-ray
1.20A
)
7NXT
(X-ray
1.20A
)
7NXW
(X-ray
1.20A
)
7NXY
(X-ray
1.20A
)
7NY4
(X-ray
1.40A
)
7NYE
(X-ray
1.40A
)
7NYF
(X-ray
1.40A
)
7NYG
(X-ray
1.40A
)
7NZ6
(X-ray
1.40A
)
7NZG
(X-ray
1.40A
)
7NZK
(X-ray
1.40A
)
7NZV
(X-ray
1.40A
)
7O07
(X-ray
1.20A
)
7O34
(X-ray
1.20A
)
7O3A
(X-ray
1.20A
)
7O3F
(X-ray
1.40A
)
7O3P
(X-ray
1.40A
)
7O3Q
(X-ray
1.80A
)
7O3R
(X-ray
1.80A
)
7O3S
(X-ray
2.00A
)
7O57
(X-ray
1.40A
)
7O59
(X-ray
1.20A
)
7O5A
(X-ray
1.80A
)
7O5C
(X-ray
1.80A
)
7O5D
(X-ray
1.80A
)
7O5F
(X-ray
1.80A
)
7O5G
(X-ray
1.80A
)
7O5O
(X-ray
1.80A
)
7O5P
(X-ray
1.80A
)
7O5S
(X-ray
1.80A
)
7O5U
(X-ray
1.80A
)
7O5X
(X-ray
1.80A
)
7O6F
(X-ray
2.00A
)
7O6G
(X-ray
1.80A
)
7O6I
(X-ray
1.80A
)
7O6J
(X-ray
1.40A
)
7O6K
(X-ray
1.40A
)
7O6M
(X-ray
1.40A
)
7O6O
(X-ray
1.40A
)
7OB5
(X-ray
1.80A
)
7OB8
(X-ray
1.80A
)
7OBC
(X-ray
1.90A
)
7OBD
(X-ray
2.00A
)
7OBG
(X-ray
1.80A
)
7OBH
(X-ray
2.00A
)
7OBK
(X-ray
1.80A
)
7OBL
(X-ray
1.80A
)
7OBS
(X-ray
1.80A
)
7OBT
(X-ray
2.30A
)
7OBX
(X-ray
1.80A
)
7OBY
(X-ray
2.10A
)
7OPW
(X-ray
1.81A
)
7OQ7
(X-ray
1.60A
)
7OQ8
(X-ray
1.43A
)
7OQ9
(X-ray
1.80A
)
7OQA
(X-ray
1.80A
)
7OQG
(X-ray
1.50A
)
7OQJ
(X-ray
1.40A
)
7OQS
(X-ray
1.34A
)
7OQU
(X-ray
1.40A
)
7OQW
(X-ray
1.90A
)
7OR3
(X-ray
1.80A
)
7OR5
(X-ray
1.80A
)
7OR7
(X-ray
1.80A
)
7OR8
(X-ray
1.80A
)
7ORG
(X-ray
1.80A
)
7ORH
(X-ray
1.80A
)
7ORS
(X-ray
1.80A
)
7ORT
(X-ray
2.33A
)
7QIK
(X-ray
2.01A
)
7QIP
(X-ray
2.65A
)
DBSNP
rs11542705
Subcellular location [CC]
Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
Mouse PG classification
NA
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