| Gene Information | |
|---|---|
| Gene Name | SFN |
| Organism | Homo sapiens (Human) |
| Gene Length | 237 |
| Protein Names | Oligoribonuclease, mitochondrial (EC 3.1.15.-) (RNA exonuclease 2 homolog) (Small fragment nuclease) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000175793 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y3B8 |
| Gene Card | REXO2 |
| Uniprot ID | Q9Y3B8 |
| Pfam | PF00929 |
| In ASD | no |
| Allosteric Prediction | yes (0.505002236) |
| Ortholog in Animals | Alpaca_ SFN ( ortholog_one2one ) GuineaPig_ SFN ( ortholog_one2one ) Macaque_ SFN ( ortholog_one2one ) Mouse_ Sfn ( ortholog_one2one ) Pig_ SFN ( ortholog_one2one ) Rat_ Sfn ( ortholog_one2many ) |
| Ohnologs | YWHAH, YWHAQ, YWHAZ, YWHAB, YWHAG |
| Paralogs | YWHAZ, YWHAE, YWHAB, YWHAQ, YWHAH, YWHAG |
| Tissue | tongue, esophagus.mucosa, suprapubic.skin |
| Tissue Specificity | Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus. {ECO:0000269|PubMed:10851236}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6J7Y (X-ray 2.20A ) 6J7Z (X-ray 2.00A ) 6J80 (X-ray 1.81A ) 6N6I (X-ray 1.43A ) 6N6J (X-ray 1.32A ) 6N6K (X-ray 1.42A ) 6RCI (X-ray 2.00A ) 6RCL (X-ray 1.97A ) 6RCN (X-ray 2.25A ) 6STY (X-ray 3.15A ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion intermembrane space {ECO:0000269|PubMed:23741365}. Mitochondrion matrix {ECO:0000269|PubMed:23741365}. Mitochondrion {ECO:0000269|PubMed:32365187}. Cytoplasm {ECO:0000269|PubMed:23741365, ECO:0000269|PubMed:32365187}. Nucleus {ECO:0000269|PubMed:32365187}.; [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:32365187}. Nucleus {ECO:0000269|PubMed:32365187}. |
| Mouse PG classification | NA |
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