| Gene Information | |
|---|---|
| Gene Name | UBQLN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 601 |
| Protein Names | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000160803 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NRR5 |
| Gene Card | UBQLN4 |
| Uniprot ID | Q9NRR5 |
| Pfam | PF00627; PF00240 |
| In ASD | no |
| Allosteric Prediction | no (-0.461238132) |
| Ortholog in Animals | Alpaca_ UBQLN4 ( ortholog_one2one ) Alpaca_ UBQLN4 ( ortholog_one2many ) Dog_ UBQLN4 ( ortholog_one2one ) GuineaPig_ UBQLN4 ( ortholog_one2one ) Macaque_ UBQLN4 ( ortholog_one2one ) Mouse_ Ubqln4 ( ortholog_one2one ) Pig_ UBQLN4 ( ortholog_one2one ) Rat_ Ubqln4 ( ortholog_one2one ) Rabbit_ UBQLN4 ( ortholog_one2one ) |
| Ohnologs | UBQLN1 |
| Paralogs | UBQLN1, UBL7, UBQLN2, UBQLN3, UBQLNL |
| Tissue | NA |
| Tissue Specificity | Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver. {ECO:0000269|PubMed:11001934}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001203(Rat);0.020833(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1465567777 rs2297792 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11001934, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:34245648}. Cytoplasm {ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738, ECO:0000269|PubMed:34245648}. Chromosome {ECO:0000269|PubMed:30612738}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99NB8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q99NB8}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:23459205}. Note=Colocalizes with the proteasome, both in nucleus and cytoplasm (PubMed:15280365). Exported from the nucleus following interaction with DESI1/POST (PubMed:29666234). In response to DNA damage and phosphorylation at Ser-318 by ATM, localizes to the nucleus and is recruited to sites of DNA damage (PubMed:30612738). {ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:30612738}. |
| Mouse PG classification | NA |
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